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Article

The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus.

Diabetes & metabolism journal - 1 Nov 2021

Pellenz Felipe Mateus, Dieter Cristine, Duarte Guilherme Coutinho Kullmann, Canani Luís Henrique, de Souza Bianca Marmontel, Crispim Daisy

Abstract excerpt

BACKGROUND: Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and pro-inflammatory pathways in pancreatic β-cells through modulation of the type I interferon signaling pathway. The rs2304256 single nucleotide polymorphism (SNP) in TYK2 gene has been associated with protection for different autoimmune diseases. However, to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34225445
DOI: 10.4093/dmj.2020.0194
PMCID: PMC8640150

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