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Article

Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy.

PloS one - 1 Jan 2018

Leon Rodriguez Daniel A, Acosta-Herrera Marialbert, Carmona F David, Dolade Nuria, Vargas Sofia, Echeverría Luis Eduardo, González Clara Isabel, Martin Javier

Abstract excerpt

Tyrosine kinase 2 (TYK2) is a member of the Janus kinases family implicated in the signal transduction of type I interferons and several interleukins. It has been described that genetic mutations within TYK2 lead to multiple deleterious effects in the immune response. In this work, we have analyzed three functional independent variants from the frequency spectrum on the TYK2 gene (common and low-frequency...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29304122
DOI: 10.1371/journal.pone.0190591
PMCID: PMC5755805

Genes

TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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