Article
Association of single-nucleotide polymorphisms in the suppressor of cytokine signaling 2 (SOCS2) gene with type 2 diabetes in the Japanese.
Genomics - 1 Apr 2006
Kato Hitoshi, Nomura Kyoko, Osabe Dai, Shinohara Shuichi, Mizumori Osamu, Katashima Rumi, Iwasaki Shoji, Nishimura Koichi, Yoshino Masayasu, Kobori Masato, Ichiishi Eiichiro, Nakamura Naoto, Yoshikawa Toshikazu, Tanahashi Toshihito, Keshavarz Parvaneh, Kunika Kiyoshi, Moritani Maki, Kudo Eiji, Tsugawa Kazue, Takata Yoichiro, Hamada Daisuke, Yasui Natsuo, Miyamoto Tatsuro, Shiota Hiroshi, Inoue Hiroshi, Itakura Mitsuo
Abstract excerpt
Several previous linkage scans in type 2 diabetes (T2D) families indicated a putative susceptibility locus on chromosome 12q15-q22, while the underlying gene for T2D has not yet been identified. We performed a region-wide association analysis on 12q15-q22, using a dense set of >500 single-nucleotide polymorphisms (SNPs), in 1492 unrelated Japanese individuals enrolled in this study. We identified an association...
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