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Article

Estimating N-acetyltransferase metabolic activity and pharmacokinetic parameters of isoniazid from genotypes in Chinese subjects.

Clinica chimica acta; international journal of clinical chemistry - 1 Jul 2009

Chen Bing, Cai Weimin, Li Jinheng, Cao Xiaomei

Abstract excerpt

BACKGROUND: To establish quantitative relationship between metabolic activity of N-acetyltransferase (NAT2) and single nucleotide polymorphisms (SNPs), and estimate pharmacokinetic parameters of isoniazid (INH) on the basis of NAT2 alleles in Chinese subjects. METHODS: Concentrations of INH and acetylisoniazid in plasma of 24 subjects were measured 0-14 h after oral administration of INH. Pharmacokinetic...

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Identifiers

PMID: 19336229
DOI: 10.1016/j.cca.2009.03.045

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NAT2

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