Article
Association between variants in inflammation and cancer-associated genes and risk and survival of cholangiocarcinoma.
Cancer medicine - 1 Oct 2015
Chaiteerakij Roongruedee, Juran Brian D, Aboelsoud Mohammed M, Harmsen William S, Moser Catherine D, Giama Nasra H, Allotey Loretta K, Mettler Teresa A, Baichoo Esha, Zhang Xiaodan, Therneau Terry M, Lazaridis Konstantinos N, Roberts Lewis R
Abstract excerpt
Genetic risk factors for cholangiocarcinoma (CCA) remain poorly understood. We assessed the effect of single-nucleotide polymorphisms (SNPs) of genes modulating inflammation or carcinogenesis on CCA risk and survival. We conducted a case-control, candidate gene association study of 370 CCA patients and 740 age-, sex-, and residential area-matched healthy controls. Eighteen functional or putatively functional SNPs...
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