Article
Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China.
Carcinogenesis - 1 Jun 2006
Sakoda Lori C, Gao Yu-Tang, Chen Bingshu E, Chen Jinbo, Rosenberg Philip S, Rashid Asif, Deng Jie, Shen Ming-Chang, Wang Bing-Sheng, Han Tian-Quan, Zhang Bai-He, Cohen-Webb Hope, Yeager Meredith, Welch Robert, Chanock Stephen, Fraumeni Joseph F, Hsing Ann W
Abstract excerpt
There is evidence that chronic inflammation predisposes to biliary tract cancer and that use of non-steroidal anti-inflammatory drugs (NSAIDs) is protective. Although the mechanisms by which NSAIDs lower cancer risk remain unclear, NSAIDs reduce prostaglandin production by blocking prostaglandin-endoperoxide synthase 2 (PTGS2, commonly known as COX-2), an enzyme induced by proinflammatory stimuli that is often...
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