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Article

Phenotype and function of macrophage polarization in monocrotaline-induced pulmonary arterial hypertension rat model.

Physiological research - 30 Apr 2021

Fan Yong, Hao Yanjie, Gao Dai, Li Guangtao, Zhang Zhuoli

Abstract excerpt

Pulmonary arterial hypertension (PAH) isa fatal disease characterized by vascular remodeling and chronic inflammation. Macrophages are the key orchestrators of inflammatory and repair responses, and have been demonstrated to be vital in the pathogenesis of PAH. However, specific phenotype of macrophage polarization (M1 & M2 macrophage) in the development of PAH and the underlying mechanisms how they work are...

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Share to Antigens, Differentiation, Myelomonocytic
Share to Human Umbilical Vein Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mannose Receptor

Share to Myocytes, Smooth Muscle

Share to Nitric Oxide Synthase Type II

Share to Pulmonary Arterial Hypertension

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Share to Vascular Remodeling

Source

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Identifiers

PMID: 33676385
DOI: 10.33549/physiolres.934456
PMCID: PMC8820576

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