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Article

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD).

Scientific reports - 17 Oct 2017

Eapen Mathew Suji, Hansbro Philip M, McAlinden Kielan, Kim Richard Y, Ward Chris, Hackett Tillie-Louise, Walters Eugene H, Sohal Sukhwinder Singh

Abstract excerpt

We explore potential dysregulation of macrophage phenotypes in COPD pathogenesis through integrated study of human small airway tissue, bronchoalveolar lavage (BAL) and an experimental murine model of COPD. We evaluated human airway tissue and BAL from healthy controls, normal lung function smokers (NLFS), and COPD subjects. Both small airways and BAL cells were immunohistochemically stained with anti-CD68 for...

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Source

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Identifiers

PMID: 29042607
DOI: 10.1038/s41598-017-13888-x
PMCID: PMC5645352

Genes

CCL22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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