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Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade

6 Nov 2024

Abstract excerpt

Macrophages are pleiotropic and diverse cells that populate all tissues of the body. Besides tissue-specific resident macrophages such as alveolar macrophages, Kupffer cells, and microglia, multiple organs harbor at least two subtypes of other resident macrophages at steady state. During certain circumstances, like tissue insult, additional subtypes of macrophages are recruited to the tissue from the monocyte...

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PMID: 39505846
DOI: 10.1038/s41467-024-53700-9

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