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Article

Unliganded fibroblast growth factor receptor 1 forms density-independent dimers.

The Journal of biological chemistry - 2 Oct 2015

Comps-Agrar Laëtitia, Dunshee Diana Ronai, Eaton Dan L, Sonoda Junichiro

Abstract excerpt

Fibroblast growth factors receptors (FGFRs) are thought to initiate intracellular signaling cascades upon ligand-induced dimerization of the extracellular domain. Although the existence of unliganded FGFR1 dimers on the surface of living cells has been proposed, this notion remains rather controversial. Here, we employed time-resolved Förster resonance energy transfer combined with SNAP- and ACP-tag labeling in...

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Source

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Identifiers

PMID: 26272615
DOI: 10.1074/jbc.M115.681395
PMCID: PMC4591805

Genes

FGFR1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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