Article
Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer.
Molecular biology of the cell - 5 Nov 2015
Valley Christopher C, Arndt-Jovin Donna J, Karedla Narain, Steinkamp Mara P, Chizhik Alexey I, Hlavacek William S, Wilson Bridget S, Lidke Keith A, Lidke Diane S
Abstract excerpt
Mutations within the epidermal growth factor receptor (EGFR/erbB1/Her1) are often associated with tumorigenesis. In particular, a number of EGFR mutants that demonstrate ligand-independent signaling are common in non-small cell lung cancer (NSCLC), including kinase domain mutations L858R (also called L834R) and exon 19 deletions (e.g., ΔL747-P753insS), which collectively make up nearly 90% of mutations in NSCLC....
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