Rewiring PTH receptor signaling: Hormone dimerization restores endosomal signaling lost in hypocalcemia-linked PTH mutant.

Abstract excerpt

G protein-coupled receptors often form dimers and heterodimers at the plasma membrane to transduce signals from various ligands, including peptide hormones. However, the role of homodimerization in regulating signaling by the parathyroid hormone (PTH) type 1 receptor (PTH1R) has remained ambiguous. Here, we show that PTH1R exists as a monomer in live cells under both basal and ligand-bound conditions, even in the...

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• Cyclic AMP
• Endosomes
• Hypocalcemia
• Hypoparathyroidism
• Molecular Dynamics Simulation