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Article

The FGFRL1 receptor is shed from cell membranes, binds fibroblast growth factors (FGFs), and antagonizes FGF signaling in Xenopus embryos.

The Journal of biological chemistry - 15 Jan 2010

Steinberg Florian, Zhuang Lei, Beyeler Michael, Kälin Roland E, Mullis Primus E, Brändli André W, Trueb Beat

Abstract excerpt

FGFRL1 (fibroblast growth factor receptor like 1) is the fifth and most recently discovered member of the fibroblast growth factor receptor (FGFR) family. With up to 50% amino acid similarity, its extracellular domain closely resembles that of the four conventional FGFRs. Its intracellular domain, however, lacks the split tyrosine kinase domain needed for FGF-mediated signal transduction. During embryogenesis of...

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Source

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Identifiers

PMID: 19920134
DOI: 10.1074/jbc.M109.058248
PMCID: PMC2804375

Genes

FGFRL1
FGF10
FGF2
FGF22
FGF3
FGF4
FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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