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Article

ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging.

Cell - 28 May 2026

Ma Kaibo, Ma Xiaojie, Shida João F, Niu Zijian, Lin Yuzhu Karlie, Mandal Saptarshi, Dobbins Alexandra, Golomb Lior, Eck Michael J, Greulich Heidi, Meyerson Matthew, Peng Chunte Sam

Abstract excerpt

Dimerization is crucial for the activation of ErbB family receptors, yet the real-time dynamics and effects of oncogenic mutations remain unclear. Here, we performed long-term, multicolor single-particle tracking (SPT) of EGFR, HER2, and HER3 in living cells using upconverting nanoparticles (UCNPs), which do not photobleach. Our technique enables continuous observation of receptor interactions, revealing details...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42054992
DOI: 10.1016/j.cell.2026.04.010
PMCID: PMC13195542

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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