Article
FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2020
Suzuki Yoshihisa, Kuzina Ekaterina, An Seong J, Tome Francisco, Mohanty Jyotidarsini, Li Wenxue, Lee Sangwon, Liu Yansheng, Lax Irit, Schlessinger Joseph
Abstract excerpt
The three members of the endocrine-fibroblast growth factor (FGF) family, FGF19, 21, and 23 are circulating hormones that regulate critical metabolic processes. FGF23 stimulates the assembly of a signaling complex composed of α-Klotho (KLA) and FGF receptor (FGFR) resulting in kinase activation, regulation of phosphate homeostasis, and vitamin D levels. Here we report that the C-terminal tail of FGF23, a region...
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