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Article

Thrombospondin-2 deficiency in growing mice alters bone collagen ultrastructure and leads to a brittle bone phenotype.

Journal of applied physiology (Bethesda, Md. : 1985) - 15 Oct 2015

Manley Eugene, Perosky Joseph E, Khoury Basma M, Reddy Anita B, Kozloff Kenneth M, Alford Andrea I

Abstract excerpt

Thrombospondin-2 (TSP2) is a matricellular protein component of the bone extracellular matrix. Long bones of adult TSP2-deficient mice have increased endosteal bone thickness due to expansion of the osteoblast progenitor cell pool, and these cells display deficits in osteoblastic potential. Here, we investigated the effects of TSP2 deficiency on whole bone geometric and mechanical properties in growing 6-wk-old...

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Identifiers

PMID: 26272319
DOI: 10.1152/japplphysiol.00340.2015
PMCID: PMC4610004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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