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Article

Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2011

Nyman Jeffry S, Lynch Conor C, Perrien Daniel S, Thiolloy Sophie, O'Quinn Elizabeth C, Patil Chetan A, Bi Xiaohong, Pharr George M, Mahadevan-Jansen Anita, Mundy Gregory R

Abstract excerpt

Matrix metalloproteinases (MMPs) are capable of processing certain components of bone tissue, including type 1 collagen, a determinant of the biomechanical properties of bone tissue, and they are expressed by osteoclasts and osteoblasts. Therefore, we posit that MMP activity can affect the ability of bone to resist fracture. To explore this possibility, we determined the architectural, compositional, and...

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Identifiers

PMID: 21611966
DOI: 10.1002/jbmr.326
PMCID: PMC3312757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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