Article
Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis.
The Journal of cell biology - 26 Jan 1998
Kyriakides T R, Zhu Y H, Smith L T, Bain S D, Yang Z, Lin M T, Danielson K G, Iozzo R V, LaMarca M, McKinney C E, Ginns E I, Bornstein P
Abstract excerpt
Thrombospondin (TSP) 2, and its close relative TSP1, are extracellular proteins whose functions are complex, poorly understood, and controversial. In an attempt to determine the function of TSP2, we disrupted the Thbs2 gene by homologous recombination in embryonic stem cells, and generated TSP2-null mice by blastocyst injection and appropriate breeding of mutant animals. Thbs2-/- mice were produced with the...
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