Article
Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010
Bassett J H Duncan, Boyde Alan, Howell Peter G T, Bassett Richard H, Galliford Thomas M, Archanco Marta, Evans Holly, Lawson Michelle A, Croucher Peter, St Germain Donald L, Galton Valerie Anne, Williams Graham R
Abstract excerpt
Hypothyroidism and thyrotoxicosis are each associated with an increased risk of fracture. Although thyroxine (T4) is the predominant circulating thyroid hormone, target cell responses are determined by local intracellular availability of the active hormone 3,5,3'-L-triiodothyronine (T3), which is generated from T4 by the type 2 deiodinase enzyme (D2). To investigate the role of locally produced T3 in bone, we...
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