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Article

TGF-beta regulates the mechanical properties and composition of bone matrix.

Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005

Balooch Guive, Balooch Mehdi, Nalla Ravi K, Schilling Stephen, Filvaroff Ellen H, Marshall Grayson W, Marshall Sally J, Ritchie Robert O, Derynck Rik, Alliston Tamara

Abstract excerpt

The characteristic toughness and strength of bone result from the nature of bone matrix, the mineralized extracellular matrix produced by osteoblasts. The mechanical properties and composition of bone matrix, along with bone mass and architecture, are critical determinants of a bone's ability to resist fracture. Several regulators of bone mass and architecture have been identified, but factors that regulate the...

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Share to Bone and Bones
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16354837
DOI: 10.1073/pnas.0507417102
PMCID: PMC1323171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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