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Article

The secreted protein thrombospondin 2 is an autocrine inhibitor of marrow stromal cell proliferation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2002

Hankenson Kurt D, Bornstein Paul

Abstract excerpt

Marrow stromal cells (MSCs) are obtained in increased number from mice in which the thrombospondin 2 (TSP2) gene is disrupted, and these cells show increased DNA synthesis in vitro. To examine more closely the role of TSP2 in the physiology and osteogenic differentiation of MSCs, an in-depth characterization of TSP2-null MSCs was conducted. Determination of TSP2 protein content by Western analysis and RNA levels...

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Identifiers

PMID: 11874233
DOI: 10.1359/jbmr.2002.17.3.415

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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