Article
Polymorphism in apoptotic BAX (-248G>A) gene but not in anti-apoptotic BCL2 (-938C>A) gene and its protein and mRNA expression are associated with cervical intraepithelial neoplasia.
Apoptosis : an international journal on programmed cell death - 1 Oct 2015
Fernandes Ana Teresa G, Rocha Natália P, Vendrame Elena, Russomano Fabio, Grinsztejn Beatriz J, Friedman Ruth K, Pinto Amanda C, Klumb Evandro M, Avvad Elyzabeth, Macedo Jacyara, Martínez-Maza Otoniel, Bonecini-Almeida Maria da Gloria
Abstract excerpt
HPV is associated with cervical cancer and plays a crucial role in tumor formation. Apoptosis is regulated by different pathways involving genes that either promote (BCL2 gene) or inhibit (BAX gene) cell death. Our goal was to determine whether the BCL2-938C>A (rs2279115) and BAX-248G>A (rs4645878) single nucleotide polymorphisms (SNPs) are associated with squamous intraepithelial neoplasia (SIL) risk, and...
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