Article
Interleukin-10 and Fas polymorphisms and susceptibility for (pre)neoplastic cervical disease.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2000
Zoodsma M, Nolte I M, Schipper M, Oosterom E, van der Steege G, de Vries E G E, Te Meerman G J, van der Zee A G J
Abstract excerpt
Infection with oncogenic types of human papillomavirus (HPV) is the main causal factor of cervical cancer and its precursor lesion (cervical intraepithelial neoplasia [CIN]). Cellular immunity may be critical in the elimination of HPV-harboring cells. Interleukin-10, a T-helper type 2 cytokine, has a suppressive effect on cell-mediated immunity. Resistance to apoptosis through the Fas pathway might enable many...
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