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Article

Lack of association between Bax promoter (-248G>A) single nucleotide polymorphism and susceptibility towards cancer: evidence from a meta-analysis.

PloS one - 1 Jan 2013

Sahu Sushil Kumar, Choudhuri Tathagata

Abstract excerpt

BACKGROUND: The Bcl-2-associated X protein (Bax) is a proapoptotic member of the Bcl-2 family known to be activated and upregulated during apoptosis. Single nucleotide polymorphisms (SNPs) in Bax promoter may participate in the process of carcinogenesis by altering its own expression and the cancer related genes. Bax-248G>A polymorphism has been implicated to alter the risk of cancer, but the listed results are...

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Identifiers

PMID: 24147019
DOI: 10.1371/journal.pone.0077534
PMCID: PMC3798304

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