Article
Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesis.
International journal of cancer - 10 Jan 2003
Lai Hung-Cheng, Sytwu Huey-Kang, Sun Chien-An, Yu Mu-Hsien, Yu Cheng-Ping, Liu Hang-Seng, Chang Cheng-Chang, Chu Tang-Yuan
Abstract excerpt
The causal role of human papillomavirus (HPV) in cervical carcinogenesis is beyond reasonable questioning. The progression from HPV infection, squamous intraepithelial lesions (SIL) to squamous cell carcinomata (SCC), however, is very uncommon and inefficient. Host genetic factors that may confer the susceptibility of disease progression are largely unknown. Apoptosis is an important fail-safe check for tumor...
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