Article
Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2016
Bhushann Meka Phanni, Jarjapu Sarika, Vishwakarma Sandeep Kumar, Nanchari Santhoshi Rani, Cingeetham Anuradha, Annamaneni Sandhya, Mukta Srinivasulu, Triveni B, Satti Vishnupriya
Abstract excerpt
BCL2 (B-cell leukemia/lymphoma 2) gene functions as antiapoptotic regulatory element and known to be associated with tumorigenesis. The SNP-938 (C>A) (rs2279115), located in the inhibitory P2 promoter of the BCL2 gene, influences differential binding affinities of transcriptional factors thereby affecting BCL2 expression. The present study is an attempt to evaluate the association between BCL2(-938C>A)...
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