Article
BAC transgenic zebrafish reveal hypothalamic enhancer activity around obesity associated SNP rs9939609 within the human FTO gene.
Genesis (New York, N.Y. : 2000) - 1 Oct 2015
Rinkwitz Silke, Geng Fan-Suo, Manning Elizabeth, Suster Maximiliano, Kawakami Koichi, Becker Thomas S
Abstract excerpt
Single Nucleotide Polymorphisms in FTO intron 1 have been associated with obesity risk, leading to the hypothesis that FTO is the obesity-related gene. However, other studies have shown that the FTO gene is part of the regulatory domain of the neighboring IRX3 gene and that enhancers in FTO intron 1 regulate IRX3. While Irx3 activity was shown to be necessary in the hypothalamus for the metabolic function of Irx3...
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