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Article

IRX3 Overexpression Enhances Ucp1 Expression In Vivo.

Frontiers in endocrinology - 1 Jan 2021

Zhang Zhiyin, Wu Qihan, He Yang, Lu Peng, Li Danjie, Yang Minglan, Gu Weiqiong, Liu Ruixin, Hong Jie, Wang Jiqiu

Abstract excerpt

Objective: The Iroquois homeobox 3 (IRX3) gene was recently reported to be a functional downstream target of a common polymorphism in the FTO gene, which encodes an obesity-associated protein; however, the role of IRX3 in energy expenditure remains unclear. Studies have revealed that the overexpression of a dominant-negative form of IRX3 in the mouse hypothalamus and adipose tissue promoted energy expenditure by...

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Share to Adipose Tissue, Brown
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33776928
DOI: 10.3389/fendo.2021.634191
PMCID: PMC7988233

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