Article
IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk.
EBioMedicine - 1 Oct 2017
Zou Yaoyu, Lu Peng, Shi Juan, Liu Wen, Yang Minglan, Zhao Shaoqian, Chen Na, Chen Maopei, Sun Yingkai, Gao Aibo, Chen Qingbo, Zhang Zhiguo, Ma Qinyun, Ning Tinglu, Ying Xiayang, Jin Jiabin, Deng Xiaxing, Shen Baiyong, Zhang Yifei, Yuan Bo, Kauderer Sophie, Liu Simin, Hong Jie, Liu Ruixin, Ning Guang, Wang Weiqing, Gu Weiqiong, Wang Jiqiu
Abstract excerpt
BACKGROUND: IRX3 was recently reported as the effector of the FTO variants. We aimed to test IRX3's roles in the browning program and to evaluate the association between the genetic variants in IRX3 and human obesity. METHODS: IRX3 expression was examined in beige adipocytes in human and mouse models, and further validated in induced beige adipocytes. The browning capacity of primary preadipocytes was assessed...
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