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Article

Positive Selection on Loci Associated with Drug and Alcohol Dependence.

PloS one - 1 Jan 2015

Sadler Brooke, Haller Gabe, Edenberg Howard, Tischfield Jay, Brooks Andy, Kramer John, Schuckit Marc, Nurnberger John, Goate Alison

Abstract excerpt

Much of the evolution of human behavior remains a mystery, including how certain disadvantageous behaviors are so prevalent. Nicotine addiction is one such phenotype. Several loci have been implicated in nicotine related phenotypes including the nicotinic receptor gene clusters (CHRNs) on chromosomes 8 and 15. Here we use 1000 Genomes sequence data from 3 populations (Africans, Asians and Europeans) to examine...

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Source

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Identifiers

PMID: 26270548
DOI: 10.1371/journal.pone.0134393
PMCID: PMC4536217

Genes

CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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