Article
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.
PLoS genetics - 11 Jul 2008
Weiss Robert B, Baker Timothy B, Cannon Dale S, von Niederhausern Andrew, Dunn Diane M, Matsunami Nori, Singh Nanda A, Baird Lisa, Coon Hilary, McMahon William M, Piper Megan E, Fiore Michael C, Scholand Mary Beth, Connett John E, Kanner Richard E, Gahring Lorise C, Rogers Scott W, Hoidal John R, Leppert Mark F
Abstract excerpt
People who begin daily smoking at an early age are at greater risk of long-term nicotine addiction. We tested the hypothesis that associations between nicotinic acetylcholine receptor (nAChR) genetic variants and nicotine dependence assessed in adulthood will be stronger among smokers who began daily nicotine exposure during adolescence. We compared nicotine addiction-measured by the Fagerstrom Test of Nicotine...
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