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Article

Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.

Molecular psychiatry - 1 Apr 2008

Berrettini W, Yuan X, Tozzi F, Song K, Francks C, Chilcoat H, Waterworth D, Muglia P, Mooser V

Abstract excerpt

Twin studies indicate that additive genetic effects explain most of the variance in nicotine dependence (ND), a construct emphasizing habitual heavy smoking despite adverse consequences, tolerance and withdrawal. To detect ND alleles, we assessed cigarettes per day (CPD) regularly smoked, in two European populations via whole genome association techniques. In these approximately 7500 persons, a common haplotype...

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Source

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Identifiers

PMID: 18227835
DOI: 10.1038/sj.mp.4002154
PMCID: PMC2507863

Genes

CPD
CHRNA3
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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