High HLA-DP Expression and Graft-versus-Host Disease.

doi:10.1056/NEJMoa1500140

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Article

High HLA-DP Expression and Graft-versus-Host Disease.

The New England journal of medicine - 13 Aug 2015

Petersdorf Effie W, Malkki Mari, O'hUigin Colm, Carrington Mary, Gooley Ted, Haagenson Michael D, Horowitz Mary M, Spellman Stephen R, Wang Tao, Stevenson Philip

Abstract excerpt

BACKGROUND: Transplantation of hematopoietic cells from unrelated donors can cure blood disorders but carries a significant risk of acute graft-versus-host disease (GVHD). The risk is higher when the recipient and donor are HLA-DPB1-mismatched, but the mechanisms leading to GVHD are unknown. The HLA-DPB1 regulatory region variant rs9277534 is associated with HLA-DPB1 expression. We tested the hypothesis that the...

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PMID: 26267621
DOI: 10.1056/NEJMoa1500140
PMCID: PMC4560117

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