Article
Clinical outcomes of HLA-DPB1 mismatches in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant.
European journal of haematology - 1 Sept 2017
Moyer Ann M, Hashmi Shahrukh K, Kroning Cynthia M, Kremers Walter K, De Goey Steven R, Patnaik Mrinal, Litzow Mark, Gastineau Dennis A, Hogan William J, Jacob Eapen K, Kreuter Justin D, Wakefield Laurie L, Gandhi Manish J
Abstract excerpt
OBJECTIVE: HLA-DPB1 matching may impact allogeneic hematopoietic stem cell transplantation (ASCT) outcomes; however, this locus is not in linkage disequilibrium with the remainder of the HLA genes. After classifying HLA-DPB1 mismatches based on T-cell epitope, avoiding non-permissive mismatches may impact survival. We tested this hypothesis at a single academic institution. METHODS: Retrospective HLA-DPB1...
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