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Machine Learning Insights into HLA Noncoding Sequence Mismatches and Their Impact on DPB1 Matching in Hematopoietic Cell Transplantation

2024-09-14

Abstract excerpt

<h4>Purpose</h4> HCT is vital for treating hematological malignancies, relying on HLA matching between unrelated patient-donor pairs to significantly reduce adverse outcomes. Recent studies recognize the potential impact of HLA-DPB1 mismatches on HCT outcomes. Multiple approaches focus on finding better-tolerated HLA-DPB1 mismatches. Additionally, recent studies suggest matching at noncoding HLA sequence may impro...

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Literature Corpus work
ceecf196-5a86-51eb-8e11-989decdfb1c7
DOI
10.1101/2024.09.13.24313580
Open publication

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Machine Learning Insights into HLA Noncoding Sequence Mismatches and Their Impact on DPB1 Matching in Hematopoietic Cell TransplantationDOI 10.1101/2024.09.13.24313580
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