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HLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants

19 Oct 2005

Abstract excerpt

Studies in unrelated donor (UD) hematopoietic stem cell transplantations (HSCT) show an effect of the matching status of HLA-DPB1 on complications. We analyzed 423 UD-HSCT pairs. Most protocols included T-cell depletion (TCD). All pairs had high-resolution tissue typing performed for 6 HLA loci. Two hundred eighty-two pairs were matched at 10 of 10 alleles (29% were DPB1 matched). In 141 HLA-mismatched pairs, 28%...

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PMID: 16234356
DOI: 10.1182/blood-2005-08-3121

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