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Article

Immunogenetics of HLA-DP — A New View of Permissible Mismatches

12 Aug 2015

Abstract excerpt

In this issue of the Journal, Petersdorf and colleagues1 report an association between high-expression HLA-DP variants in patients receiving hematopoietic-cell transplantation for severe blood disorders and acute graft-versus-host disease (GVHD). Acute GVHD is a major hurdle in successful treatment.HLA-DP molecules are immunoglobulin family cell-surface heterodimers encoded by the polymorphic DPA1 and DPB1 loci...

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Identifiers

PMID: 26267627
DOI: 10.1056/nejme1505539

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Related research

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Immunogenetics of HLA-DP — A New View of Permissible MismatchesPMID 26267627Read ↗

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The degree of matching at HLA-DPB1 predicts for acute graft-versus-host disease and disease relapse following haematopoietic stem cell transplantationSemantic proximity Read ↗

Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1Semantic proximity Read ↗

A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation.Semantic proximity Read ↗

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Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain.Semantic proximity Read ↗

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