Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.

Nature - 3 Sept 2015

Koren Shany, Reavie Linsey, Couto Joana Pinto, De Silva Duvini, Stadler Michael B, Roloff Tim, Britschgi Adrian, Eichlisberger Tobias, Kohler Hubertus, Aina Olulanu, Cardiff Robert D, Bentires-Alj Mohamed

Abstract excerpt

The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor cells contributing to its proliferative and regenerative potential. A key issue in breast cancer biology is the effect of genomic lesions in specific mammary cell lineages on tumour heterogeneity and progression. The impact of transforming events on fate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Dedifferentiation
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Animal

Share to Multipotent Stem Cells

Share to Neoplasm Invasiveness

Share to Phosphatidylinositol 3-Kinases

Source

Identifiers

PMID: 26266975
DOI: 10.1038/nature14669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.PMID 26266975Read ↗

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.Semantic proximity Read ↗

Multipotent luminal mammary cancer stem cells model tumor heterogeneitySemantic proximity Read ↗

Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.Semantic proximity Read ↗

Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.Semantic proximity Read ↗

Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models.Semantic proximity Read ↗

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancersSemantic proximity Read ↗

Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate DysregulationSemantic proximity Read ↗

Evolutionary fingerprints of EMT in pancreatic cancersSemantic proximity Read ↗

Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations.Semantic proximity Read ↗

Early lineage segregation of multipotent embryonic mammary gland progenitors.Semantic proximity Read ↗

Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.Semantic proximity Read ↗

Longitudinal single cell RNA-sequencing of <i>Pik3ca</i> <sup>H1047R</sup> -driven mammary tumorigenesis reveals coordinated transformation of epithelial and fibroblast transcriptional statesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.