Article
Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.
PloS one - 1 Jan 2012
Fredebohm Johannes, Boettcher Michael, Eisen Christian, Gaida Matthias M, Heller Anette, Keleg Shereen, Tost Jörg, Greulich-Bode Karin M, Hotz-Wagenblatt Agnes, Lathrop Mark, Giese Nathalia A, Hoheisel Jörg D
Abstract excerpt
Standard cancer cell lines do not model the intratumoural heterogeneity situation sufficiently. Clonal selection leads to a homogeneous population of cells by genetic drift. Heterogeneity of tumour cells, however, is particularly critical for therapeutically relevant studies, since it is a prerequisite for acquiring drug resistance and reoccurrence of tumours. Here, we report the isolation of a highly...
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