Article
Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations.
Oncogene - 17 Jan 2013
Yuan W, Stawiski E, Janakiraman V, Chan E, Durinck S, Edgar K A, Kljavin N M, Rivers C S, Gnad F, Roose-Girma M, Haverty P M, Fedorowicz G, Heldens S, Soriano R H, Zhang Z, Wallin J J, Johnson L, Merchant M, Modrusan Z, Stern H M, Seshagiri S
Abstract excerpt
Oncogenic mutations in PIK3CA, which encodes the phosphoinositide-3-kinase (PI3K) catalytic subunit p110α, occur in ∼25% of human breast cancers. In this study, we report the development of a knock-in mouse model for breast cancer where the endogenous Pik3ca allele was modified to allow tissue-specific conditional expression of a frequently found Pik3ca(H1047R) (Pik3ca(e20H1047R)) mutant allele. We found that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.