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Multipotent luminal mammary cancer stem cells model tumor heterogeneity

14 Oct 2015

Abstract excerpt

INTRODUCTION: The diversity of human breast cancer subtypes has led to the hypothesis that breast cancer is actually a number of different diseases arising from cells at various stages of differentiation. The elusive nature of the cell(s) of origin thus hampers approaches to eradicate the disease. METHODS: Clonal cell lines were isolated from primary transgenic polyomavirus middle T (PyVmT) luminal tumors....

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PMID: 26467658
DOI: 10.1186/s13058-015-0615-y

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