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Article

Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.

Cancer research - 1 Jul 2011

Meyer Dominique S, Brinkhaus Heike, Müller Urs, Müller Matthias, Cardiff Robert D, Bentires-Alj Mohamed

Abstract excerpt

The phosphoinositide 3-kinase (PI3K) signaling cascade, a key mediator of cellular survival, growth, and metabolism, is frequently altered in human cancer. Activating mutations in PIK3CA, which encodes the α-catalytic subunit of PI3K, occur in approximately 30% of breast cancers. These mutations result in constitutive activity of the enzyme and are oncogenic, but it is not known whether they are sufficient to...

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Share to Cell Transformation, Neoplastic
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Experimental

Share to Mice, Inbred BALB C

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Share to Receptors, Estrogen

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Identifiers

PMID: 21482677
DOI: 10.1158/0008-5472.CAN-10-3827

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Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.PMID 21482677Read ↗

Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.Semantic proximity Read ↗

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047RSemantic proximity Read ↗

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.Semantic proximity Read ↗

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Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations.Semantic proximity Read ↗

PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.Semantic proximity Read ↗

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells.Semantic proximity Read ↗

Physiological expression of PI3K H1047R mutation reveals its anti-metastatic potential in ErbB2-driven breast cancer.Semantic proximity Read ↗

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