The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer.

doi:10.1371/journal.pone.0134496

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Article

The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer.

PloS one - 1 Jan 2015

Putra Andika C, Eguchi Hidetaka, Lee Kian Leong, Yamane Yuko, Gustine Ewita, Isobe Takeshi, Nishiyama Masahiko, Hiyama Keiko, Poellinger Lorenz, Tanimoto Keiji

Abstract excerpt

Hypoxia-inducible factor-2α (HIF-2α, or EPAS1) is important for cancer progression, and is a putative biomarker for poor prognosis for non-small cell lung cancer (NSCLC). However, molecular mechanisms underlying the EPAS1 overexpression are not still fully understood. We explored a role of a single nucleotide polymorphism (SNP), rs13419896 located within intron 1 of the EPAS1 gene in regulation of its expression....

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PMID: 26263511
DOI: 10.1371/journal.pone.0134496
PMCID: PMC4532412

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EPAS1

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