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Article

Hypoxia pathway genetic variants predict survival of non-small-cell lung cancer patients receiving platinum-based chemotherapy.

Carcinogenesis - 1 Apr 2017

Li Rong, Gu Jiang, Heymach John V, Shu Xiang, Zhao Lina, Han Baohui, Ye Yuanqing, Roth Jack, Wu Xifeng

Abstract excerpt

Hypoxia is a hallmark of solid tumors and has been implicated in the development of advanced disease and poor clinical outcome. In this multi-stage study, we aimed to assess whether genetic variations in hypoxia pathway genes might affect overall survival (OS) in patients with advanced-stage non-small cell lung cancer (NSCLC). We genotyped 598 potentially functional and tagging single nucleotide polymorphisms...

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Source

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Identifiers

PMID: 28186269
DOI: 10.1093/carcin/bgx014
PMCID: PMC5963494

Genes

EXO1
RPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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