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Hypoxia pathway genetic variants predict survival of non-small-cell lung cancer patients receiving platinum-based chemotherapy.

Carcinogenesis - 1 Apr 2017

Li Rong, Gu Jiang, Heymach John V, Shu Xiang, Zhao Lina, Han Baohui, Ye Yuanqing, Roth Jack, Wu Xifeng

Abstract excerpt

Hypoxia is a hallmark of solid tumors and has been implicated in the development of advanced disease and poor clinical outcome. In this multi-stage study, we aimed to assess whether genetic variations in hypoxia pathway genes might affect overall survival (OS) in patients with advanced-stage non-small cell lung cancer (NSCLC). We genotyped 598 potentially functional and tagging single nucleotide polymorphisms...

Topics

Adult
Aged
Aged, 80 and over
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
Female
Genotype
Humans
Hypoxia
Lung Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Organoplatinum Compounds

Polymorphism, Single Nucleotide

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 28186269
DOI: 10.1093/carcin/bgx014
PMCID: PMC5963494

Genes

EXO1
RPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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