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Potentially functional variants of ERRFI1 in hypoxia-related genes predict survival of non-small cell lung cancer patients.

Cancer medicine - 1 Aug 2024

Wang Huilin, Liu Hongliang, Lu Guojun, Tang Xiaozhun, Luo Sheng, Du Mulong, Christiani David C, Wei Qingyi

Abstract excerpt

BACKGROUND: Hypoxia is often involved in tumor microenvironment, and the hypoxia-induced signaling pathways play a key role in aggressive cancer phenotypes, including angiogenesis, immune evasion, and therapy resistance. However, it is unknown what role genetic variants in the hypoxia-related genes play in survival of patients with non-small cell lung cancer (NSCLC). METHODS: We evaluated the associations between...

Topics

Aged
Female
Humans
Male
Middle Aged
Adaptor Proteins, Signal Transducing
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
Genotype
Linkage Disequilibrium
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Prognosis

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Open in PubMed Open full text

Identifiers

PMID: 39096122
DOI: 10.1002/cam4.70073
PMCID: PMC11297539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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