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Article

HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers.

The American journal of pathology - 1 May 2010

Baba Yoshifumi, Nosho Katsuhiko, Shima Kaori, Irahara Natsumi, Chan Andrew T, Meyerhardt Jeffrey A, Chung Daniel C, Giovannucci Edward L, Fuchs Charles S, Ogino Shuji

Abstract excerpt

Tissue hypoxia commonly occurs in tumors. Hypoxia- inducible factor (HIF)-1 and HIF-2, which are essential mediators of cellular response to hypoxia, regulate gene expression for tumor angiogenesis, glucose metabolism, and resistance to oxidative stress. Their key regulatory subunits, HIF1A (HIF-1alpha) and endothelial PAS domain protein 1 (EPAS1; HIF-2alpha), are overexpressed and associated with patient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20363910
DOI: 10.2353/ajpath.2010.090972
PMCID: PMC2861094

Genes

EPAS1
PTGS2
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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