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Article

A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter.

Cancer research - 1 Jan 2005

Liu Wanqing, Innocenti Federico, Wu Michael H, Desai Apurva A, Dolan M Eileen, Cook Edwin H, Ratain Mark J

Abstract excerpt

The epidermal growth factor receptor (EGFR) plays a prominent role in cell growth and development. Its regulation in humans is complex and incompletely understood. In this study, 12 new polymorphisms were discovered in the 5'-regulatory region of EGFR gene and 2 common single nucleotide polymorphisms (-216G/T and -191C/A) were found in the essential promoter area, one of which is located in a Sp1 recognition site...

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Identifiers

PMID: 15665278

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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