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Article

EPAS1 and VEGFA Polymorphisms Modulate COPD Susceptibility in a High-Altitude Population: A Case-Control Study.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Lin Lin, Zhang Yi, Fu Xiang, Zhang Yangjie, Wang Yunchao, Yang Zhen, Ma Xiaoming, Wang Xinhua

Abstract excerpt

Background: The onset and progression of Chronic Obstructive Pulmonary Disease (COPD) are influenced by both environmental and genetic factors. Persistent hypoxia at high altitudes is a major environmental stressor. Under hypoxic conditions, EPAS1 is stably expressed and activates its downstream target gene VEGFA; however, the underlying mechanisms remain unclear. Methods: We conducted a case-control study in...

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Identifiers

PMID: 42206079
DOI: 10.2147/COPD.S585856
PMCID: PMC13206275

Genes

EPAS1
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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