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Article

Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia.

Nucleic acids research - 2 Nov 2016

Roche Olga, Deguiz María Laura, Tiana María, Galiana-Ribote Clara, Martinez-Alcazar Daniel, Rey-Serra Carlos, Ranz-Ribeiro Beatriz, Casitas Raquel, Galera Raúl, Fernández-Navarro Isabel, Sánchez-Cuéllar Silvia, Bernard Virginie, Ancochea Julio, Wasserman Wyeth W, García-Rio Francisco, Jimenez Benilde, Del Peso Luis

Abstract excerpt

A wide range of diseases course with an unbalance between the consumption of oxygen by tissues and its supply. This situation triggers a transcriptional response, mediated by the hypoxia inducible factors (HIFs), that aims to restore oxygen homeostasis. Little is known about the inter-individual variation in this response and its role in the progression of disease. Herein, we sought to identify common genetic...

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Identifiers

PMID: 27625398
DOI: 10.1093/nar/gkw811
PMCID: PMC5100585

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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