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Article

Defects in the Mitochondrial Genome of Dogs with Recurrent Tumours.

International journal of molecular sciences - 14 Dec 2024

Kowal Krzysztof, Ziółkowska-Twarowska Kaja, Tkaczyk-Wlizło Angelika, Grzybowska-Szatkowska Ludmiła, Ślaska Brygida

Abstract excerpt

This study presents a comprehensive analysis of mitochondrial DNA (mtDNA) variations in dogs diagnosed with primary and recurrent tumours, employing Oxford Nanopore Technologies (ONT) for sequencing. Our investigation focused on mtDNA extracted from blood and tumour tissues of three dogs, aiming to pinpoint polymorphisms, mutations, and heteroplasmy levels that could influence mitochondrial function in cancer...

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Identifiers

PMID: 39769179
DOI: 10.3390/ijms252413414

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